Prostate-Specific Antigen (PSA), Free-to-Total Ratio

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About Our Prostate-Specific Antigen (PSA), Free-to-Total Ratio

The PSA, Free-to-Total Ratio Test is a specialized blood test that provides deeper insight into prostate health when PSA levels are elevated. It measures the ratio of free PSA (PSA not bound to proteins in the blood) compared to total PSA (both free and bound PSA combined).

While a total PSA test shows how much PSA is present overall, this ratio helps clarify why PSA may be elevated. It is especially useful when total PSA results fall into a borderline range and additional clarity is needed before moving forward with more invasive testing.

What Is Included In This Test?

This test analyzes two key values to calculate a clinically meaningful ratio:

Total PSA: The total amount of prostate-specific antigen in the blood
Free PSA: The portion of PSA that circulates unbound

What the Ratio Indicates:

A lower free-to-total PSA ratio may be associated with a higher likelihood of prostate cancer
A higher ratio is more commonly linked to benign prostate conditions such as benign prostatic hyperplasia (BPH) or prostatitis

By adding context to elevated PSA levels, this test helps reduce uncertainty and supports more informed decision-making about next steps.

Who Should Consider This Test?

The PSA, Free-to-Total Ratio Test is intended for adult men who need more detailed evaluation of their PSA results.

You should consider this test if you:

Have a borderline total PSA result, typically between 4.0 and 10.0 ng/mL
Want to better assess prostate cancer risk before proceeding with a biopsy
Are monitoring prostate health and want greater clarity around elevated PSA levels
Have known prostate enlargement or inflammation and need to distinguish between benign and concerning causes
Prefer a more precise, risk-based approach to prostate health monitoring

This test does not diagnose prostate cancer on its own, but it plays a critical role in guiding follow-up testing and reducing unnecessary invasive procedures.

If your PSA results are unclear, the PSA, Free-to-Total Ratio Test can provide the additional insight needed to move forward with confidence.

Convenient, No-Appointment Testing

To complete your test:

Order online through our website
Use the lab locator to find a nearby testing location
Walk in; no appointment required
Access your results securely in your HealthLabs.com account within one to three business days

110% Price Guarantee!

If you find the same test for a lower price from a comparable provider, contact us. We not only match the price, we beat it by an additional 10 percent of the difference.

Common Questions:

How is this test different from a total PSA test?

A total PSA test measures the overall PSA level, while the free-to-total ratio helps determine whether an elevated PSA is more likely due to prostate cancer or a benign condition.

Why is the free-to-total PSA ratio important?

The ratio helps clarify the cause of elevated PSA levels. Lower ratios are more commonly associated with prostate cancer, while higher ratios often suggest benign prostate conditions.

Will anyone see my results besides me?

Your results are stored in your secure online account. They are not shared with anyone else. If you choose, you can print or download them to share with your own doctor.

Do I need to fast before this test?

Fasting is not required for this panel. You can eat and drink normally unless your doctor has given you other instructions.

Can I talk to someone about my results?

Yes. If your results come back abnormal or if you simply have questions, our team is here to support you. You can text our Patient Services team at 1800-579-3914, anytime between 8am and 8pm.

Can I use insurance to pay for this test?

In order to ensure your privacy, we do not bill insurance directly, but you may use HSA or FSA funds. This keeps your results and testing completely private from insurers. We can also provide you with an itemized receipt for insurance reimbursement purposes if you need it.